Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
نویسندگان
چکیده
منابع مشابه
Tityus serrulatus Scorpion Venom: In Vitro Tests and Their Correlation with In Vivo Lethal Dose Assay
Scorpion stings are the main cause of human envenomation in Brazil and, for the treatment of victims, the World Health Organization (WHO) recommends the use of antivenoms. The first step to achieve effective antivenom is to use a good quality venom pool and to evaluate it, with LD50 determination as the most accepted procedure. It is, however, time-consuming and requires advanced technical trai...
متن کاملNeutralizing Effects of Mimosa tenuiflora Extracts against Inflammation Caused by Tityus serrulatus Scorpion Venom
Scorpion bite represents a significant and serious public health problem in certain regions of Brazil, as well as in other parts of the world. Inflammatory mediators are thought to be involved in the systemic and local immune response induced by Tityus serrulatus scorpion envenomation. The aim of this study was to evaluate the effect of extracts of Mimosa tenuiflora on model envenomation. In mi...
متن کاملThe dynamics of cytokine d nitric oxide secretion in mice injected with Tityus serrulatus scorpion venom.
AIMS The effects of Tityus serrulatus venom (TSV) were analysed with respect to the susceptibility of four isogenic mouse, the symptoms following injection of venom and the inflammatory mediators in an experimental model of severe envenomation induced in mice. METHODS The susceptibility was analysed by lethal dose (LD50) determination, including the symptoms observed during envenomating and g...
متن کاملEffect of toxin-g from Tityus serrulatus scorpion venom on gastric emptying in rats.
The effect of toxin-gamma from Tityus serrulatus scorpion venom on the gastric emptying of liquids was studied in 176 young adult male Wistar rats (2-3 months of age) divided into subgroups of 8 animals each. Toxin-gamma was injected i.v. at doses of 25, 37.5, 50 or 100 micrograms/kg and the effect on gastric emptying was assessed 30 min and 8 h later. A time-course study was also performed by ...
متن کاملAge effects on the pharmacokinetics of tityustoxin from Tityus serrulatus scorpion venom in rats.
The pharmacokinetics of scorpion venom and its toxins has been investigated in experimental models using adult animals, although, severe scorpion accidents are associated more frequently with children. We compared the effect of age on the pharmacokinetics of tityustoxin, one of the most active principles of Tityus serrulatus venom, in young male/female rats (21-22 days old, N=5-8) and in adult ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Toxicon
سال: 2014
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2014.06.018